OpenEye, Cadence Molecular Sciences – a division of Cadence Design Systems – is an industry leader in computational molecular design through rapid, robust, and scalable software, consulting services, and Orion®, the only cloud-native fully integrated software-as-a-service molecular modeling platform. Combining unlimited computation and storage with powerful tools for data sharing, visualization and analysis in a customizable development platform, Orion offers unprecedented capabilities for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. OpenEye, Cadence Molecular Sciences is headquartered in Santa Fe, N.M., with offices in Boston, Mass.; Cologne, Germany; and Tokyo, Japan.
Over the last eight years, OpenEye has developed the field's most advanced large-scale compute platform, Orion, built on Amazon Web Services. In this position, you will be working at the cutting edge of cloud computing, Python/C++ development, and advanced MD simulation techniques to investigate the mechanistic details of passive membrane permeability of drug-like molecules. Your work will have the potential to make a major impact in drug discovery research and will likely be used by many pharmaceutical and biotech companies around the world.
The successful candidate will have shared responsibility for delivering established products, building new technologies into customer solutions, and establishing new algorithms for molecular modeling and machine learning in drug discovery. You will be able to deploy your solutions on Orion, the most exciting cloud platform available today for drug discovery.
The team you will join includes several PhD level scientific developers with expertise in computational chemistry, statistical thermodynamics, and molecular modeling. We are also skilled C++ and Python developers, and experts in code optimization, large-scale software infrastructure development and deployment. You will fit in if you enjoy writing high quality scientific code and contributing to scientific computations on a large-scale.
What you’ll do:
- Write state-of-the-art scientific software tools for drug discovery
- 3D molecular modeling including ligand-based and structure-based design
- Bio-active conformer generation
- 3D modeling of molecular properties and interactions
- Optimize in-situ molecular structures, and calculate free energies
- Help customers solve their drug discovery problems
What we use:
- Python, C++, Java, C#
- Cmake, swig, git, Jupyter, conda, pip, Atlassian tools: JIRA, bitbucket, Fisheye
- Multi-platform development environment
- Orion: A cloud-platform for high-performance scientific computing
What you should have:
- Master or PhD in Physics, Chemistry, Computational Biology or related field
- Desire to learn new ideas and technologies
- 3-5+ years of experience using Python and/or C++ for scientific development
- Knowledge of molecular modeling and drug discovery literature
- Thorough understanding of professional software development practices & tools
The following are a PLUS, but not required:
- Teamwork
- Attention to detail
- Excellent communication skills
- Scientific and technical innovation
- Curiosity and creativity
- Experience working on large scale software projects
- The ability to write new code when necessary, use available code when appropriate
- Ability to work under a development schedule, balancing features and delivery deadlines